Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. [electronic resource]
- Cancer letters Feb 2011
- 161-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1872-7980
10.1016/j.canlet.2010.11.010 doi
Adenoma, Liver Cell--chemically induced Animals Cell Proliferation--drug effects Central Nervous System Depressants--administration & dosage DNA Damage Dose-Response Relationship, Drug Ethanol--administration & dosage Gene Frequency Hepatitis, Alcoholic--etiology Immunohistochemistry Liver--drug effects Liver Neoplasms, Experimental--chemically induced Male Mice Mice, Inbred Strains Mutagenesis--drug effects Oxidative Stress--drug effects Proliferating Cell Nuclear Antigen--analysis Time Factors beta Catenin--metabolism ras Proteins--genetics