TY  - GEN
AU  - Villanueva,Jessie
AU  - Vultur,Adina
AU  - Lee,John T
AU  - Somasundaram,Rajasekharan
AU  - Fukunaga-Kalabis,Mizuho
AU  - Cipolla,Angela K
AU  - Wubbenhorst,Bradley
AU  - Xu,Xiaowei
AU  - Gimotty,Phyllis A
AU  - Kee,Damien
AU  - Santiago-Walker,Ademi E
AU  - Letrero,Richard
AU  - D'Andrea,Kurt
AU  - Pushparajan,Anitha
AU  - Hayden,James E
AU  - Brown,Kimberly Dahlman
AU  - Laquerre,Sylvie
AU  - McArthur,Grant A
AU  - Sosman,Jeffrey A
AU  - Nathanson,Katherine L
AU  - Herlyn,Meenhard
TI  - Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
SN  - 1878-3686
PY  - 2011///0106
KW  - Cell Line, Tumor
KW  - Drug Resistance, Neoplasm
KW  - Humans
KW  - MAP Kinase Signaling System
KW  - Melanoma
KW  - drug therapy
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Phosphatidylinositol 3-Kinases
KW  - physiology
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Phosphorylation
KW  - Proto-Oncogene Proteins B-raf
KW  - Proto-Oncogene Proteins c-akt
KW  - metabolism
KW  - Receptor, IGF Type 1
KW  - raf Kinases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.ccr.2010.11.023
ER  -