Ismail, M A H <br/><br/>
Computer--based drug design, synthesis and biological evaluation of new pyrimidinone derivatives linked to arylpiperazine and 2'-carbethoxy-biphenylylmethyl moeities as alpha1-adrenoceptor antagonists and angiotensin II AT1 receptor antagonists.  [electronic resource] 

 -  Die Pharmazie  Nov 2010 
 - 794-800 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0031-7144 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adrenergic alpha-1 Receptor Antagonists--chemical synthesis<br/>Angiotensin II Type 1 Receptor Blockers--chemical synthesis<br/>Animals<br/>Biphenyl Compounds--chemical synthesis<br/>Blood Pressure--drug effects<br/>Computer Simulation<br/>Computer-Aided Design<br/>Drug Design<br/>Indicators and Reagents<br/>Models, Molecular<br/>Piperazines--chemistry<br/>Protein Conformation<br/>Pyrimidines--chemical synthesis<br/>Pyrimidinones--chemical synthesis<br/>Rats<br/>Software<br/>Structure-Activity Relationship