TY  - GEN
AU  - Motta,Paola
AU  - Pons,Nicoletta
AU  - Pagliarusco,Sabrina
AU  - Pellegatti,Mario
AU  - Bonomo,Fiorenza
TI  - Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4
SN  - 1521-009X
PY  - 2011///0614
KW  - Adult
KW  - Cells, Cultured
KW  - Computer Simulation
KW  - Cytochrome P-450 CYP3A
KW  - genetics
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Drug Evaluation, Preclinical
KW  - methods
KW  - Drug Interactions
KW  - Enzyme Induction
KW  - drug effects
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Female
KW  - Hepatocytes
KW  - Humans
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Microsomes, Liver
KW  - Middle Aged
KW  - Models, Molecular
KW  - Neurokinin-1 Receptor Antagonists
KW  - Neurotransmitter Agents
KW  - analysis
KW  - Piperazines
KW  - Piperidines
KW  - Recombinant Proteins
KW  - antagonists & inhibitors
KW  - Young Adult
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.110.035071
ER  -