Motta, Paola <br/><br/>
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Mar 2011 
 - 363-72 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.110.035071  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Cells, Cultured<br/>Computer Simulation<br/>Cytochrome P-450 CYP3A--genetics<br/>Cytochrome P-450 CYP3A Inhibitors<br/>Drug Evaluation, Preclinical--methods<br/>Drug Interactions<br/>Enzyme Induction--drug effects<br/>Enzyme Inhibitors--pharmacology<br/>Female<br/>Hepatocytes--drug effects<br/>Humans<br/>Male<br/>Metabolic Clearance Rate--drug effects<br/>Microsomes, Liver--drug effects<br/>Middle Aged<br/>Models, Molecular<br/>Neurokinin-1 Receptor Antagonists<br/>Neurotransmitter Agents--analysis<br/>Piperazines--analysis<br/>Piperidines--analysis<br/>Recombinant Proteins--antagonists & inhibitors<br/>Young Adult