Takato, Hazuki <br/><br/>
The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice.  [electronic resource] 

 -  Experimental lung research  Mar 2011 
 - 101-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-0499 
<br/><br/><label>Standard No.: </label>10.3109/01902148.2010.520815  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Bronchoalveolar Lavage Fluid--chemistry<br/>Chemokine CCL2--metabolism<br/>Chemokines, CC--metabolism<br/>Chymases--antagonists & inhibitors<br/>Cytokines--metabolism<br/>Hydroxyproline--metabolism<br/>Macrophage Inflammatory Proteins--metabolism<br/>Male<br/>Mast Cells--drug effects<br/>Mice<br/>Mice, Inbred ICR<br/>Neutrophils--drug effects<br/>Pulmonary Fibrosis--chemically induced<br/>Serine Endopeptidases--biosynthesis<br/>Silicon Dioxide<br/>Sulfonamides--pharmacology<br/>Thiophenes--pharmacology<br/>Transforming Growth Factor beta1--metabolism