APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells. [electronic resource]
- European journal of haematology Mar 2011
- 206-15 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1600-0609
10.1111/j.1600-0609.2010.01557.x doi
Antineoplastic Agents--administration & dosage Aza Compounds--administration & dosage Base Sequence Bridged Bicyclo Compounds, Heterocyclic--administration & dosage Cytarabine--administration & dosage DNA Primers--genetics Daunorubicin--administration & dosage Drug Resistance, Neoplasm Drug Synergism Female Gene Expression--drug effects Genes, p53 Humans Karyotyping Leukemia, Myeloid, Acute--drug therapy Male Mutation Proto-Oncogene Proteins c-bcl-2--metabolism Tumor Cells, Cultured Tumor Suppressor Protein p14ARF--metabolism Vidarabine--administration & dosage bcl-2-Associated X Protein--metabolism