O'Malley, Dervla

Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism. [electronic resource] - American journal of physiology. Gastrointestinal and liver physiology Feb 2011 - G241-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-1547

10.1152/ajpgi.00385.2010 doi


Acetylcholine--metabolism
Animals
Cholinergic Agonists--metabolism
Colon--innervation
Female
Ganglia--physiopathology
In Vitro Techniques
Interleukin-1beta--pharmacology
Interleukin-6--blood
Interleukin-8--pharmacology
Irritable Bowel Syndrome--etiology
Male
Maternal Deprivation
Mitogen-Activated Protein Kinases--metabolism
NF-kappa B--metabolism
Neurons--drug effects
Rats
Rats, Sprague-Dawley
Receptors, Interleukin-6--metabolism
Recombinant Proteins--pharmacology
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Submucous Plexus--physiopathology
Tumor Necrosis Factor-alpha--pharmacology