FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. [electronic resource]
- Toxicology and applied pharmacology Feb 2011
- 8-15 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1096-0333
10.1016/j.taap.2010.11.007 doi
Animals Antineoplastic Combined Chemotherapy Protocols--pharmacology Apoptosis--drug effects Apoptosis Regulatory Proteins--metabolism Bcl-2-Like Protein 11 Carcinoma, Squamous Cell--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Cisplatin--pharmacology Cyclin-Dependent Kinase Inhibitor p27--metabolism Dose-Response Relationship, Drug Drug Synergism Forkhead Box Protein O3 Forkhead Transcription Factors--genetics Humans Male Membrane Proteins--metabolism Mice Mice, Inbred BALB C Mice, Nude Molecular Targeted Therapy Phosphorylation Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-akt--antagonists & inhibitors S-Phase Kinase-Associated Proteins--metabolism Sirolimus--pharmacology Time Factors Tongue Neoplasms--drug therapy Tumor Burden--drug effects Xenograft Model Antitumor Assays