Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. [electronic resource]
- Nature chemical biology Dec 2010
- 900-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1552-4469
10.1038/nchembio.467 doi
Affinity Labels Alzheimer Disease--metabolism Amyloid beta-Peptides--metabolism Amyloid beta-Protein Precursor--metabolism Animals Apoptosis--drug effects Brain--pathology Disulfides--metabolism Endoplasmic Reticulum--enzymology Enzyme Inhibitors--pharmacology Exons--genetics Humans Huntingtin Protein Huntington Disease--metabolism Molecular Chaperones--physiology Nerve Tissue Proteins--chemistry Nuclear Proteins--chemistry PC12 Cells Protein Disulfide-Isomerases--antagonists & inhibitors Protein Folding Proteostasis Deficiencies--pathology Rats Signal Transduction--physiology Small Molecule Libraries