Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells. [electronic resource]
- Molecular cancer therapeutics Nov 2010
- 2879-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-10-0504 doi
Aldehyde Dehydrogenase--metabolism Aldehyde Dehydrogenase 1 Family Animals Apoptosis--drug effects Carcinoma--pathology Carcinoma, Squamous Cell Down-Regulation--drug effects Gamma Rays--therapeutic use Head and Neck Neoplasms--pathology Humans Hyaluronan Receptors--metabolism Isoenzymes--metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasms, Squamous Cell--pathology Neoplastic Stem Cells--drug effects Radiation Tolerance--drug effects Radiation-Sensitizing Agents--pharmacology Retinal Dehydrogenase Squamous Cell Carcinoma of Head and Neck Triterpenes--pharmacology Tumor Cells, Cultured Xenograft Model Antitumor Assays