Jin, Yi <br/><br/>
CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Feb 2011 
 - 191-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.110.035378  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aryl Hydrocarbon Hydroxylases--genetics<br/>Biotransformation<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 Enzyme System--genetics<br/>Cytochrome P450 Family 4<br/>Fingolimod Hydrochloride<br/>Humans<br/>In Vitro Techniques<br/>Mass Spectrometry<br/>Microsomes, Liver--metabolism<br/>Molecular Structure<br/>Multiple Sclerosis, Relapsing-Remitting--drug therapy<br/>Oxidation-Reduction<br/>Propylene Glycols--chemistry<br/>Sphingosine--analogs & derivatives<br/>Transfection