Kretzer, Nicole M

A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor . [electronic resource] - The Journal of biological chemistry Dec 2010 - 41863-73 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M110.183723 doi


Breast Neoplasms--metabolism
Butyrophenones--chemistry
Cell Line, Tumor
Estrogen Receptor alpha--antagonists & inhibitors
Female
Fluorescence Polarization
Gene Expression Regulation, Neoplastic
Genes, Reporter
Humans
Leupeptins--pharmacology
Models, Chemical
Mucin-1--metabolism
Proteasome Endopeptidase Complex--metabolism
Purines--chemistry
RNA, Messenger--metabolism
Response Elements
Tamoxifen--analogs & derivatives