Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Feb 2011
- 468-78 p. digital
Publication Type: Journal Article
1521-0103
10.1124/jpet.110.172817 doi
Analgesics--pharmacology Animals Anti-Inflammatory Agents--pharmacology Cells, Cultured Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors--pharmacokinetics Fluoroquinolones--pharmacokinetics Gastrointestinal Transit--drug effects Humans Macaca mulatta Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Motor Activity--drug effects Nitric Oxide Synthase Type I--antagonists & inhibitors Nitric Oxide Synthase Type II--antagonists & inhibitors Protein Multimerization Pyrazines--pharmacokinetics