Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. [electronic resource]
- Journal of medicinal chemistry Nov 2010
- 8047-58 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm100780c doi
Animals Antineoplastic Agents--chemical synthesis Cell Line, Tumor Cell Proliferation--drug effects Drug Design Drug Screening Assays, Antitumor Humans Insulin-Like Growth Factor Binding Protein 1--metabolism Male Mice Mice, Nude Models, Molecular Neoplasm Transplantation Organophosphates--chemical synthesis Phosphorylation Quinolones--chemical synthesis Structure-Activity Relationship Transplantation, Heterologous