Chou, Li-Chen

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. [electronic resource] - Journal of medicinal chemistry Nov 2010 - 8047-58 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm100780c doi


Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Design
Drug Screening Assays, Antitumor
Humans
Insulin-Like Growth Factor Binding Protein 1--metabolism
Male
Mice
Mice, Nude
Models, Molecular
Neoplasm Transplantation
Organophosphates--chemical synthesis
Phosphorylation
Quinolones--chemical synthesis
Structure-Activity Relationship
Transplantation, Heterologous