Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex signaling axis in adenoid cystic carcinoma. [electronic resource]
- Molecular pharmacology Jan 2011
- 106-18 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1521-0111
10.1124/mol.110.066910 doi
Animals Carcinoma, Adenoid Cystic--drug therapy Cell Line Cell Line, Tumor Chickens Curcumin--pharmacology Female I-kappa B Proteins--antagonists & inhibitors Mice Mice, Inbred BALB C Mice, Nude NF-kappa B--antagonists & inhibitors Phosphatidylinositol 3-Kinase--metabolism Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins c-akt--metabolism Random Allocation Rats Signal Transduction--drug effects TOR Serine-Threonine Kinases--antagonists & inhibitors Xenograft Model Antitumor Assays--methods