TY  - GEN
AU  - Ghosal,Anima
AU  - Lu,Xiaowen
AU  - Penner,Natalia
AU  - Gao,Lan
AU  - Ramanathan,Ragu
AU  - Chowdhury,Swapan K
AU  - Kishnani,Narendra S
AU  - Alton,Kevin B
TI  - Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist
SN  - 1521-009X
PY  - 2011///0705
KW  - Astemizole
KW  - pharmacology
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Cytochrome P-450 Enzyme System
KW  - Humans
KW  - Hydroxylation
KW  - Ketoconazole
KW  - Lactones
KW  - blood
KW  - Microsomes
KW  - Microsomes, Liver
KW  - Pyridines
KW  - Receptor, PAR-1
KW  - Receptors, Thrombin
KW  - antagonists & inhibitors
KW  - Recombinant Proteins
KW  - Tranylcypromine
KW  - Platelet Aggregation Inhibitors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.110.035493
ER  -