Ghosal, Anima <br/><br/>
Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jan 2011 
 - 30-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.110.035493  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Astemizole--pharmacology<br/>Cytochrome P-450 CYP3A--metabolism<br/>Cytochrome P-450 Enzyme System--metabolism<br/>Humans<br/>Hydroxylation<br/>Ketoconazole--pharmacology<br/>Lactones--blood<br/>Microsomes--metabolism<br/>Microsomes, Liver--metabolism<br/>Pyridines--blood<br/>Receptor, PAR-1--metabolism<br/>Receptors, Thrombin--antagonists & inhibitors<br/>Recombinant Proteins--metabolism<br/>Tranylcypromine--pharmacology<br/>Platelet Aggregation Inhibitors