TY - GEN AU - Steidle,Sabine AU - Martínez-Sobrido,Luis AU - Mordstein,Markus AU - Lienenklaus,Stefan AU - García-Sastre,Adolfo AU - Stäheli,Peter AU - Kochs,Georg TI - Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response SN - 1098-5514 PY - 2011///0106 KW - Animals KW - Blotting, Western KW - Cells, Cultured KW - Cleavage And Polyadenylation Specificity Factor KW - metabolism KW - Embryo, Mammalian KW - cytology KW - Female KW - Fibroblasts KW - Fluorescent Antibody Technique KW - Glycine KW - chemistry KW - Immunoprecipitation KW - Influenza A virus KW - pathogenicity KW - Interferons KW - Luciferases KW - Lung KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Mutation KW - genetics KW - Orthomyxoviridae Infections KW - RNA, Viral KW - Viral Nonstructural Proteins KW - Virulence KW - physiology KW - Virus Replication N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1128/JVI.00701-10 ER -