TY  - GEN
AU  - Scullion,G A
AU  - Kendall,D A
AU  - Marsden,C A
AU  - Sunter,D
AU  - Pardon,M-C
TI  - Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis
SN  - 1873-7064
PY  - 2011///1122
KW  - Adrenergic alpha-2 Receptor Antagonists
KW  - administration & dosage
KW  - Aging
KW  - genetics
KW  - Amyloid beta-Peptides
KW  - biosynthesis
KW  - Amyloid beta-Protein Precursor
KW  - Animals
KW  - Astrocytes
KW  - drug effects
KW  - Gliosis
KW  - drug therapy
KW  - Humans
KW  - Longitudinal Studies
KW  - Memory Disorders
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - Piperoxan
KW  - Plaque, Amyloid
KW  - Presenilin-1
KW  - Pyrroles
KW  - Receptors, Adrenergic, alpha-2
KW  - physiology
KW  - Treatment Outcome
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.neuropharm.2010.09.002
ER  -