Scullion, G A <br/><br/>
Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis.  [electronic resource] 

 -  Neuropharmacology   
 - 223-34 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1873-7064 
<br/><br/><label>Standard No.: </label>10.1016/j.neuropharm.2010.09.002  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adrenergic alpha-2 Receptor Antagonists--administration & dosage<br/>Aging--genetics<br/>Amyloid beta-Peptides--biosynthesis<br/>Amyloid beta-Protein Precursor--biosynthesis<br/>Animals<br/>Astrocytes--drug effects<br/>Gliosis--drug therapy<br/>Humans<br/>Longitudinal Studies<br/>Memory Disorders--genetics<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Transgenic<br/>Piperoxan--administration & dosage<br/>Plaque, Amyloid--drug therapy<br/>Presenilin-1--biosynthesis<br/>Pyrroles--administration & dosage<br/>Receptors, Adrenergic, alpha-2--physiology<br/>Treatment Outcome