TY  - GEN
AU  - Guo,Danny
AU  - Kassiri,Zamaneh
AU  - Basu,Ratnadeep
AU  - Chow,Fung L
AU  - Kandalam,Vijay
AU  - Damilano,Federico
AU  - Liang,Wenbin
AU  - Izumo,Seigo
AU  - Hirsch,Emilio
AU  - Penninger,Josef M
AU  - Backx,Peter H
AU  - Oudit,Gavin Y
TI  - Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress
SN  - 1524-4571
PY  - 2010///1215
KW  - Adrenergic beta-Antagonists
KW  - administration & dosage
KW  - Animals
KW  - Antigens, CD
KW  - metabolism
KW  - Biomechanical Phenomena
KW  - Cadherins
KW  - Cardiomegaly
KW  - drug therapy
KW  - Cell Adhesion
KW  - Cells, Cultured
KW  - Class Ib Phosphatidylinositol 3-Kinase
KW  - deficiency
KW  - Cyclic AMP
KW  - Cyclic AMP Response Element-Binding Protein
KW  - Disease Models, Animal
KW  - Extracellular Matrix
KW  - Fibroblasts
KW  - enzymology
KW  - Glycogen Synthase Kinase 3
KW  - Heart Failure
KW  - Male
KW  - Matrix Metalloproteinase 13
KW  - Matrix Metalloproteinase 14
KW  - Matrix Metalloproteinase 2
KW  - Matrix Metalloproteinases
KW  - Mechanotransduction, Cellular
KW  - drug effects
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Myocardial Contraction
KW  - Myocardium
KW  - Myocytes, Cardiac
KW  - Phosphorylation
KW  - Propranolol
KW  - Proto-Oncogene Proteins c-akt
KW  - Stress, Mechanical
KW  - Time Factors
KW  - Ventricular Remodeling
KW  - beta Catenin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1161/CIRCRESAHA.110.229054
ER  -