Guo, Danny <br/><br/>
Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.  [electronic resource] 

 -  Circulation research  Nov 2010 
 - 1275-89 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1524-4571 
<br/><br/><label>Standard No.: </label>10.1161/CIRCRESAHA.110.229054  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adrenergic beta-Antagonists--administration & dosage<br/>Animals<br/>Antigens, CD--metabolism<br/>Biomechanical Phenomena<br/>Cadherins--metabolism<br/>Cardiomegaly--drug therapy<br/>Cell Adhesion<br/>Cells, Cultured<br/>Class Ib Phosphatidylinositol 3-Kinase--deficiency<br/>Cyclic AMP--metabolism<br/>Cyclic AMP Response Element-Binding Protein--metabolism<br/>Disease Models, Animal<br/>Extracellular Matrix--metabolism<br/>Fibroblasts--enzymology<br/>Glycogen Synthase Kinase 3--metabolism<br/>Heart Failure--enzymology<br/>Male<br/>Matrix Metalloproteinase 13--metabolism<br/>Matrix Metalloproteinase 14--metabolism<br/>Matrix Metalloproteinase 2--metabolism<br/>Matrix Metalloproteinases--metabolism<br/>Mechanotransduction, Cellular--drug effects<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Knockout<br/>Myocardial Contraction<br/>Myocardium--enzymology<br/>Myocytes, Cardiac--enzymology<br/>Phosphorylation<br/>Propranolol--administration & dosage<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Stress, Mechanical<br/>Time Factors<br/>Ventricular Remodeling--drug effects<br/>beta Catenin--metabolism