TY  - GEN
AU  - Sofia,Michael J
AU  - Bao,Donghui
AU  - Chang,Wonsuk
AU  - Du,Jinfa
AU  - Nagarathnam,Dhanapalan
AU  - Rachakonda,Suguna
AU  - Reddy,P Ganapati
AU  - Ross,Bruce S
AU  - Wang,Peiyuan
AU  - Zhang,Hai-Ren
AU  - Bansal,Shalini
AU  - Espiritu,Christine
AU  - Keilman,Meg
AU  - Lam,Angela M
AU  - Steuer,Holly M Micolochick
AU  - Niu,Congrong
AU  - Otto,Michael J
AU  - Furman,Phillip A
TI  - Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
SN  - 1520-4804
PY  - 2010///1109
KW  - Animals
KW  - Antiviral Agents
KW  - chemical synthesis
KW  - Cell Line
KW  - Crystallography, X-Ray
KW  - Dogs
KW  - Drug Resistance, Viral
KW  - Esters
KW  - Hepacivirus
KW  - drug effects
KW  - Hepatocytes
KW  - metabolism
KW  - Humans
KW  - In Vitro Techniques
KW  - Liver
KW  - Macaca fascicularis
KW  - Mutation
KW  - Prodrugs
KW  - Rats
KW  - Replicon
KW  - Sofosbuvir
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Uridine Monophosphate
KW  - analogs & derivatives
KW  - Viral Nonstructural Proteins
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm100863x
ER  -