Sofia, Michael J <br/><br/>
Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.  [electronic resource] 

 -  Journal of medicinal chemistry  Oct 2010 
 - 7202-18 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm100863x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antiviral Agents--chemical synthesis<br/>Cell Line<br/>Crystallography, X-Ray<br/>Dogs<br/>Drug Resistance, Viral<br/>Esters<br/>Hepacivirus--drug effects<br/>Hepatocytes--metabolism<br/>Humans<br/>In Vitro Techniques<br/>Liver--metabolism<br/>Macaca fascicularis<br/>Mutation<br/>Prodrugs--chemical synthesis<br/>Rats<br/>Replicon<br/>Sofosbuvir<br/>Stereoisomerism<br/>Structure-Activity Relationship<br/>Uridine Monophosphate--analogs & derivatives<br/>Viral Nonstructural Proteins--antagonists & inhibitors