TY - GEN AU - Simoni,Elena AU - Bergamini,Christian AU - Fato,Romana AU - Tarozzi,Andrea AU - Bains,Sandip AU - Motterlini,Roberto AU - Cavalli,Andrea AU - Bolognesi,Maria Laura AU - Minarini,Anna AU - Hrelia,Patrizia AU - Lenaz,Giorgio AU - Rosini,Michela AU - Melchiorre,Carlo TI - Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents SN - 1520-4804 PY - 2010///1109 KW - Animals KW - Antineoplastic Agents KW - chemical synthesis KW - Antioxidants KW - Cattle KW - Cell Line KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Curcumin KW - analogs & derivatives KW - Drug Screening Assays, Antitumor KW - Endothelial Cells KW - Endothelium, Vascular KW - Enzyme Activation KW - Fibroblasts KW - cytology KW - Heme Oxygenase-1 KW - metabolism KW - Humans KW - In Vitro Techniques KW - Mice KW - Mitochondria KW - Neuroprotective Agents KW - Oxidative Stress KW - Polyamines KW - Reactive Oxygen Species KW - Stereoisomerism KW - Structure-Activity Relationship N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/jm100637k ER -