TY - GEN AU - Wang,Shiyi AU - Ionescu,Roxana AU - Peekhaus,Norbert AU - Leung,Jin-Yu AU - Ha,Sha AU - Vlasak,Josef TI - Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions SN - 1873-3778 PY - 2010///1230 KW - Antibodies, Monoclonal KW - chemistry KW - Calorimetry, Differential Scanning KW - Chromatography, High Pressure Liquid KW - methods KW - Chromatography, Ion Exchange KW - Circular Dichroism KW - Glycosylation KW - Humans KW - Hydrogen-Ion Concentration KW - Methionine KW - Models, Molecular KW - Oxidation-Reduction KW - Peptide Mapping KW - Protein Conformation KW - Protein Denaturation KW - Protein Processing, Post-Translational KW - Spectrophotometry, Ultraviolet KW - Temperature N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.chroma.2010.08.044 ER -