TY - GEN AU - Nishijima,Takeshi AU - Piriz,Joaquin AU - Duflot,Sylvie AU - Fernandez,Ana M AU - Gaitan,Gema AU - Gomez-Pinedo,Ulises AU - Verdugo,Jose M Garcia AU - Leroy,Felix AU - Soya,Hideaki AU - Nuñez,Angel AU - Torres-Aleman,Ignacio TI - Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS SN - 1097-4199 PY - 2010///1001 KW - Action Potentials KW - drug effects KW - Analysis of Variance KW - Animals KW - Biophysics KW - methods KW - Blood-Brain Barrier KW - Body Temperature KW - Cells, Cultured KW - Central Nervous System KW - Coculture Techniques KW - Digoxigenin KW - metabolism KW - Drug Interactions KW - Electric Stimulation KW - Endothelial Cells KW - Enzyme-Linked Immunosorbent Assay KW - Excitatory Amino Acid Antagonists KW - pharmacology KW - Functional Laterality KW - Glutamic Acid KW - Humans KW - Immunoprecipitation KW - Insulin-Like Growth Factor I KW - Low Density Lipoprotein Receptor-Related Protein-1 KW - Matrix Metalloproteinase 9 KW - Microdialysis KW - Microscopy, Immunoelectron KW - Nerve Tissue Proteins KW - Neural Pathways KW - Neuroglia KW - Neurons KW - Protein Transport KW - Rats KW - Rats, Wistar KW - Receptor, IGF Type 1 KW - Regional Blood Flow KW - Time Factors KW - Vibrissae KW - innervation N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.neuron.2010.08.007 ER -