TY  - GEN
AU  - Ahlem,Clarence
AU  - Kennedy,Michael
AU  - Page,Theodore
AU  - Bell,David
AU  - Delorme,Evelyn
AU  - Villegas,Sonia
AU  - Reading,Chris
AU  - White,Steven
AU  - Stickney,Dwight
AU  - Frincke,James
TI  - 17α-alkynyl 3α, 17β-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism
SN  - 1573-0646
PY  - 2012///0508
KW  - Administration, Oral
KW  - Androstanols
KW  - administration & dosage
KW  - Androstenedione
KW  - blood
KW  - Animals
KW  - Antineoplastic Agents, Hormonal
KW  - Biotransformation
KW  - Cell Line, Tumor
KW  - Chromatography, Liquid
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - biosynthesis
KW  - Dehydroepiandrosterone
KW  - Dogs
KW  - Drug Administration Schedule
KW  - Enzyme Induction
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Female
KW  - Humans
KW  - Macaca fascicularis
KW  - Male
KW  - Metabolomics
KW  - Mice
KW  - Microsomes, Liver
KW  - drug effects
KW  - Prostatic Neoplasms
KW  - drug therapy
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Cytoplasmic and Nuclear
KW  - Species Specificity
KW  - Tandem Mass Spectrometry
KW  - Testosterone
KW  - Transcriptional Activation
KW  - Transfection
N1  - Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study
UR  - https://doi.org/10.1007/s10637-010-9517-0
ER  -