Murakami, Eisuke <br/><br/>
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.  [electronic resource] 

 -  The Journal of biological chemistry  Nov 2010 
 - 34337-47 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M110.161802  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antiviral Agents--pharmacokinetics<br/>Carboxylic Ester Hydrolases--metabolism<br/>Cathepsin A--metabolism<br/>Cell Line<br/>Hepacivirus--physiology<br/>Hepatocytes--metabolism<br/>Humans<br/>Hydrolysis<br/>Nucleoside-Phosphate Kinase--metabolism<br/>Prodrugs--pharmacokinetics<br/>RNA, Viral--metabolism<br/>Sofosbuvir<br/>Stereoisomerism<br/>Uridine Monophosphate--analogs & derivatives<br/>Viral Nonstructural Proteins--antagonists & inhibitors<br/>Virus Replication--drug effects