Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes. [electronic resource]
- Journal of thrombosis and haemostasis : JTH Dec 2010
- 2708-17 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7836
10.1111/j.1538-7836.2010.04036.x doi
Anticoagulants--chemistry Cell Line, Tumor Cytochrome P-450 Enzyme System--genetics Fluorescence Resonance Energy Transfer Gene Expression Regulation, Enzymologic--drug effects Genes, Reporter Humans Pregnane X Receptor Receptors, Steroid--drug effects Reverse Transcriptase Polymerase Chain Reaction Stereoisomerism Transcriptional Activation Two-Hybrid System Techniques Up-Regulation--drug effects Warfarin--chemistry