TY  - GEN
AU  - Murray,Christopher W
AU  - Carr,Maria G
AU  - Callaghan,Owen
AU  - Chessari,Gianni
AU  - Congreve,Miles
AU  - Cowan,Suzanna
AU  - Coyle,Joseph E
AU  - Downham,Robert
AU  - Figueroa,Eva
AU  - Frederickson,Martyn
AU  - Graham,Brent
AU  - McMenamin,Rachel
AU  - O'Brien,M Alistair
AU  - Patel,Sahil
AU  - Phillips,Theresa R
AU  - Williams,Glyn
AU  - Woodhead,Andrew J
AU  - Woolford,Alison J-A
TI  - Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency
SN  - 1520-4804
PY  - 2010///0916
KW  - Aminopyridines
KW  - chemical synthesis
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Crystallography, X-Ray
KW  - Databases, Factual
KW  - Drug Design
KW  - HSP90 Heat-Shock Proteins
KW  - antagonists & inhibitors
KW  - Ligands
KW  - Magnetic Resonance Spectroscopy
KW  - Models, Molecular
KW  - Phenols
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - Resorcinols
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm100059d
ER  -