The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts. [electronic resource]
- International journal of cancer Jun 2011
- 2748-58 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-0215
10.1002/ijc.25611 doi
Animals Apoptosis Axitinib Blotting, Western Bone Marrow Neoplasms--drug therapy Child Drug Synergism Endothelium, Vascular--cytology Humans Imidazoles--therapeutic use Indazoles--therapeutic use Male Mice Mice, Nude Neovascularization, Pathologic--drug therapy Neuroblastoma--blood supply Phosphorylation Sirolimus--pharmacology Stem Cells--drug effects Tumor Cells, Cultured Vascular Endothelial Growth Factor Receptor-1--antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-3--antagonists & inhibitors Xenograft Model Antitumor Assays