TY  - GEN
AU  - Luciani,Alessandro
AU  - Villella,Valeria Rachela
AU  - Esposito,Speranza
AU  - Brunetti-Pierri,Nicola
AU  - Medina,Diego
AU  - Settembre,Carmine
AU  - Gavina,Manuela
AU  - Pulze,Laura
AU  - Giardino,Ida
AU  - Pettoello-Mantovani,Massimo
AU  - D'Apolito,Maria
AU  - Guido,Stefano
AU  - Masliah,Eliezer
AU  - Spencer,Brian
AU  - Quaratino,Sonia
AU  - Raia,Valeria
AU  - Ballabio,Andrea
AU  - Maiuri,Luigi
TI  - Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
SN  - 1476-4679
PY  - 2010///1022
KW  - Acetylcysteine
KW  - pharmacology
KW  - Adaptor Proteins, Signal Transducing
KW  - genetics
KW  - Adolescent
KW  - Adult
KW  - Animals
KW  - Antioxidants
KW  - Apoptosis Regulatory Proteins
KW  - Autophagy
KW  - drug effects
KW  - Beclin-1
KW  - Cell Line
KW  - Cystamine
KW  - Cystic Fibrosis
KW  - drug therapy
KW  - Cystic Fibrosis Transmembrane Conductance Regulator
KW  - antagonists & inhibitors
KW  - Epithelial Sodium Channels
KW  - GTP-Binding Proteins
KW  - Heat-Shock Proteins
KW  - metabolism
KW  - Humans
KW  - Inflammation
KW  - Membrane Proteins
KW  - Mice
KW  - Mice, Inbred CFTR
KW  - Mice, Inbred Strains
KW  - Mice, Transgenic
KW  - Microtubule-Associated Proteins
KW  - Models, Biological
KW  - Nasal Polyps
KW  - Organometallic Compounds
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Protein Binding
KW  - physiology
KW  - Protein Glutamine gamma Glutamyltransferase 2
KW  - Protein Transport
KW  - Reactive Oxygen Species
KW  - Respiratory Mucosa
KW  - cytology
KW  - Salicylates
KW  - Sequestosome-1 Protein
KW  - Small Ubiquitin-Related Modifier Proteins
KW  - Transglutaminases
KW  - Young Adult
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/ncb2090
ER  -