The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. [electronic resource]
- Molecular pharmacology Nov 2010
- 837-45 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1521-0111
10.1124/mol.110.064188 doi
Black or African American Amino Acid Substitution Cell Line Cholesterol, HDL--blood Enkephalin, Ala(2)-MePhe(4)-Gly(5)---pharmacology Female Genes, Reporter Genotype Humans Luciferases--biosynthesis Mutagenesis, Site-Directed Mutation, Missense Naloxone--pharmacology Naltrexone--pharmacology Narcotic Antagonists--pharmacology Opioid Peptides--pharmacology Peptides--pharmacology Polymorphism, Single Nucleotide Protein Isoforms--agonists Protein Transport Radioligand Assay Receptors, Opioid, mu--agonists Signal Transduction White People