Beneficial read-through of a USH1C nonsense mutation by designed aminoglycoside NB30 in the retina. [electronic resource]
- Investigative ophthalmology & visual science Dec 2010
- 6671-80 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1552-5783
10.1167/iovs.10-5741 doi
Adaptor Proteins, Signal Transducing--genetics Aminoglycosides--pharmacology Animals Blotting, Western Cell Culture Techniques Cell Cycle Proteins Codon, Nonsense--drug effects Cytoskeletal Proteins Dose-Response Relationship, Drug Electroporation Gene Expression--physiology Gentamicins--pharmacology HEK293 Cells--metabolism Humans In Situ Nick-End Labeling Mice Mice, Inbred C57BL Microscopy, Fluorescence Paromomycin--pharmacology Protein Biosynthesis--drug effects Retina--drug effects Transfection