TY  - GEN
AU  - Rajamäki,Kristiina
AU  - Lappalainen,Jani
AU  - Oörni,Katariina
AU  - Välimäki,Elina
AU  - Matikainen,Sampsa
AU  - Kovanen,Petri T
AU  - Eklund,Kari K
TI  - Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
SN  - 1932-6203
PY  - 2010///1028
KW  - Blotting, Western
KW  - Carrier Proteins
KW  - genetics
KW  - Caspase 1
KW  - metabolism
KW  - Caspase Inhibitors
KW  - Cathepsin B
KW  - Cells, Cultured
KW  - Cholesterol
KW  - chemistry
KW  - Chromatography, Thin Layer
KW  - Cytochalasin D
KW  - pharmacology
KW  - Cytoplasm
KW  - Humans
KW  - Inflammation
KW  - Interleukin-1beta
KW  - Lipopolysaccharides
KW  - Lysosomes
KW  - drug effects
KW  - Macrophages
KW  - Microscopy, Confocal
KW  - Monocytes
KW  - NLR Family, Pyrin Domain-Containing 3 Protein
KW  - Phagocytosis
KW  - Potassium
KW  - RNA, Small Interfering
KW  - Reverse Transcriptase Polymerase Chain Reaction
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0011765
ER  -