TY - GEN AU - Green,Alexa S AU - Chapuis,Nicolas AU - Maciel,Thiago Trovati AU - Willems,Lise AU - Lambert,Mireille AU - Arnoult,Christophe AU - Boyer,Olivier AU - Bardet,Valerie AU - Park,Sophie AU - Foretz,Marc AU - Viollet,Benoit AU - Ifrah,Norbert AU - Dreyfus,François AU - Hermine,Olivier AU - Moura,Ivan Cruz AU - Lacombe,Catherine AU - Mayeux,Patrick AU - Bouscary,Didier AU - Tamburini,Jerome TI - The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation SN - 1528-0020 PY - 2010///1221 KW - AMP-Activated Protein Kinase Kinases KW - Adaptor Proteins, Signal Transducing KW - metabolism KW - Animals KW - Biocatalysis KW - drug effects KW - Cell Cycle Proteins KW - Cell Death KW - Cell Proliferation KW - Enzyme Activation KW - Hematopoietic Stem Cells KW - cytology KW - Humans KW - Leukemia, Myeloid, Acute KW - enzymology KW - Metformin KW - pharmacology KW - Mice KW - Neoplasm Proteins KW - biosynthesis KW - Phosphoproteins KW - Phosphorylation KW - Polyribosomes KW - Protein Biosynthesis KW - Protein Kinases KW - Protein Serine-Threonine Kinases KW - Signal Transduction KW - TOR Serine-Threonine Kinases KW - Tuberous Sclerosis Complex 2 Protein KW - Tumor Suppressor Proteins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1182/blood-2010-02-269837 ER -