Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption. [electronic resource]
- The Journal of neuroscience : the official journal of the Society for Neuroscience Jul 2010
- 10169-76 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1529-2401
10.1523/JNEUROSCI.2601-10.2010 doi
Alanine--genetics Alcohol Drinking--drug therapy Analysis of Variance Animals Benzazepines--therapeutic use Central Nervous System Depressants--administration & dosage Disease Models, Animal Dopamine--metabolism Dose-Response Relationship, Drug Drinking Behavior--drug effects Drug Combinations Ethanol--administration & dosage Gene Expression Regulation--drug effects Leucine--genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Mutation--genetics Neurons--drug effects Nicotinic Agonists--therapeutic use Proto-Oncogene Proteins c-fos--metabolism Quinoxalines--therapeutic use Receptors, Nicotinic--deficiency Tyrosine 3-Monooxygenase--metabolism Varenicline Ventral Tegmental Area--cytology