TY  - GEN
AU  - Niculescu-Duvaz,Dan
AU  - Niculescu-Duvaz,Ion
AU  - Suijkerbuijk,Bart M J M
AU  - Ménard,Delphine
AU  - Zambon,Alfonso
AU  - Nourry,Arnaud
AU  - Davies,Lawrence
AU  - Manne,Helen A
AU  - Friedlos,Frank
AU  - Ogilvie,Lesley
AU  - Hedley,Douglas
AU  - Takle,Andrew K
AU  - Wilson,David M
AU  - Pons,Jean-Francois
AU  - Coulter,Tom
AU  - Kirk,Ruth
AU  - Cantarino,Neus
AU  - Whittaker,Steven
AU  - Marais,Richard
AU  - Springer,Caroline J
TI  - Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
SN  - 1464-3391
PY  - 2010///1230
KW  - Animals
KW  - Binding Sites
KW  - Computer Simulation
KW  - Female
KW  - Furans
KW  - chemistry
KW  - Humans
KW  - Imidazoles
KW  - Mice
KW  - Mutation
KW  - Protein Kinase Inhibitors
KW  - chemical synthesis
KW  - Protein Structure, Tertiary
KW  - Proto-Oncogene Proteins B-raf
KW  - antagonists & inhibitors
KW  - Pyrazoles
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmc.2010.06.031
ER  -