Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice. [electronic resource]
- Epilepsy research Sep 2010
- 39-48 p. digital
Animals Anticonvulsants--therapeutic use Dose-Response Relationship, Drug Drug Tolerance--physiology Male Mice Morphine--therapeutic use NG-Nitroarginine Methyl Ester--pharmacology Nitric Oxide--antagonists & inhibitors Pentylenetetrazole--toxicity Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors Seizures--chemically induced Signal Transduction--drug effects