A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. [electronic resource]
- British journal of cancer Jul 2010
- 401-10 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1532-1827
10.1038/sj.bjc.6605763 doi
Antibodies, Monoclonal--therapeutic use Antibodies, Monoclonal, Humanized Antigens, CD Breast Neoplasms--drug therapy Cadherins--genetics Cell Line, Tumor Colony-Forming Units Assay DNA Primers Down-Regulation Female Gene Amplification Genes, erbB-2 Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins--antagonists & inhibitors Neoplasm Proteins--genetics Oligonucleotide Array Sequence Analysis Open Reading Frames Protein-Tyrosine Kinases--antagonists & inhibitors RNA, Messenger--genetics Receptor, ErbB-2--antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction Syk Kinase Transfection Trastuzumab