Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells. [electronic resource]
- The Journal of biological chemistry Sep 2010
- 29078-90 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1083-351X
10.1074/jbc.M110.105296 doi
Alkaline Ceramidase--genetics Antineoplastic Agents--therapeutic use Blotting, Western Cell Line, Tumor Ceramides--metabolism Chromatography, High Pressure Liquid Fenretinide--therapeutic use Flow Cytometry HeLa Cells Humans Neoplasms--drug therapy Polymerase Chain Reaction RNA, Small Interfering--genetics Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry