Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Oct 2010
- 32-41 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1521-0103
10.1124/jpet.110.170225 doi
Animals Cell Line Colon--metabolism Dextran Sulfate Gastrointestinal Agents--therapeutic use Humans Inflammatory Bowel Diseases--chemically induced Leprostatic Agents--therapeutic use Liver--metabolism Luciferases--metabolism Male Metabolomics Mice Mice, Inbred C57BL Mice, Knockout Microsomes--metabolism NF-kappa B--biosynthesis Pregnane X Receptor RNA, Messenger--biosynthesis Receptors, Steroid--agonists Rifampin--therapeutic use Rifamycins--therapeutic use Rifaximin Stearoyl-CoA Desaturase--metabolism