Bruyère, Arnaud <br/><br/>
Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.  [electronic resource] 

 -  Molecular pharmaceutics  Oct 2010 
 - 1596-607 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1543-8392 
<br/><br/><label>Standard No.: </label>10.1021/mp100015x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP Binding Cassette Transporter, Subfamily B<br/>ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism<br/>ATP Binding Cassette Transporter, Subfamily G, Member 2<br/>ATP-Binding Cassette Transporters--metabolism<br/>Administration, Oral<br/>Adult<br/>Aged<br/>Aged, 80 and over<br/>Biological Availability<br/>Cytochrome P-450 CYP3A--metabolism<br/>Humans<br/>Intestinal Absorption<br/>Intestine, Small--metabolism<br/>Microsomes--metabolism<br/>Middle Aged<br/>Models, Biological<br/>Neoplasm Proteins--metabolism<br/>Pharmacokinetics<br/>Tissue Distribution