TY - GEN AU - Groenendijk,Floris H AU - Taal,Walter AU - Dubbink,Hendrikus J AU - Haarloo,Cathleen R AU - Kouwenhoven,Mathilde C AU - van den Bent,Martin J AU - Kros,Johan M AU - Dinjens,Winand N M TI - MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation SN - 1573-7373 PY - 2011///0505 KW - Adult KW - Astrocytoma KW - genetics KW - Brain Neoplasms KW - DNA Methylation KW - DNA Modification Methylases KW - DNA Repair Enzymes KW - Disease Progression KW - Female KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Male KW - Middle Aged KW - Mutation KW - Prognosis KW - Promoter Regions, Genetic KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins N1 - Publication Type: Journal Article UR - https://doi.org/10.1007/s11060-010-0274-x ER -