Zhang, J G

A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin. [electronic resource] - Drug metabolism letters Dec 2010 - 185-94 p. digital

Publication Type: Journal Article

1874-0758

10.2174/187231210792928224 doi


Aryl Hydrocarbon Hydroxylases--biosynthesis
Biological Assay--standards
Blotting, Western
Cells, Cultured
Cytochrome P-450 CYP1A2--biosynthesis
Cytochrome P-450 CYP2B6
Cytochrome P-450 CYP3A--biosynthesis
Dose-Response Relationship, Drug
Endpoint Determination
Enzyme Induction
Hepatocytes--drug effects
Humans
Oxidoreductases, N-Demethylating--biosynthesis
Phenobarbital--pharmacology
RNA, Messenger--biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Rifampin--pharmacology
Substrate Specificity
Time Factors
beta-Naphthoflavone--pharmacology