TY  - GEN
AU  - Drews,Andreas
AU  - Bovens,Stefanie
AU  - Roebrock,Kirsten
AU  - Sunderkötter,Cord
AU  - Reinhardt,Dirk
AU  - Schäfers,Michael
AU  - van der Velde,Andrea
AU  - Schulze Elfringhoff,Alwine
AU  - Fabian,Jörg
AU  - Lehr,Matthias
TI  - 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity
SN  - 1520-4804
PY  - 2010///0825
KW  - Administration, Topical
KW  - Animals
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - chemical synthesis
KW  - Bile
KW  - metabolism
KW  - Biological Availability
KW  - Blood Platelets
KW  - drug effects
KW  - Cytosol
KW  - enzymology
KW  - Dermatitis, Contact
KW  - drug therapy
KW  - Drug Stability
KW  - Glucuronides
KW  - Group IV Phospholipases A2
KW  - antagonists & inhibitors
KW  - Humans
KW  - Indoles
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Microsomes, Liver
KW  - Phenyl Ethers
KW  - Rats
KW  - Solubility
KW  - Structure-Activity Relationship
KW  - Thermodynamics
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm1001088
ER  -