Drews, Andreas <br/><br/>
1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.  [electronic resource] 

 -  Journal of medicinal chemistry  Jul 2010 
 - 5165-78 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm1001088  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Topical<br/>Animals<br/>Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis<br/>Bile--metabolism<br/>Biological Availability<br/>Blood Platelets--drug effects<br/>Cytosol--enzymology<br/>Dermatitis, Contact--drug therapy<br/>Drug Stability<br/>Glucuronides--metabolism<br/>Group IV Phospholipases A2--antagonists & inhibitors<br/>Humans<br/>Indoles--chemical synthesis<br/>Mice<br/>Mice, Inbred C57BL<br/>Microsomes, Liver--metabolism<br/>Phenyl Ethers--chemical synthesis<br/>Rats<br/>Solubility<br/>Structure-Activity Relationship<br/>Thermodynamics