Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. [electronic resource]
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Dec 2010
- 2657-68 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1523-4681
10.1002/jbmr.168 doi
Animals Apoptosis--drug effects Cell Line Cell Nucleus--metabolism Culture Media, Conditioned--pharmacology Cyclic AMP-Dependent Protein Kinases--metabolism Dexamethasone--pharmacology Dinoprostone--metabolism Glucocorticoids--pharmacology Glycogen Synthase Kinase 3--metabolism Glycogen Synthase Kinase 3 beta Indomethacin--pharmacology Lithium Chloride--pharmacology Mice Models, Biological Osteocytes--cytology Phosphatidylinositol 3-Kinase Protective Agents--pharmacology Protein Stability--drug effects Protein Transport--drug effects Proto-Oncogene Proteins c-akt--metabolism Receptors, Prostaglandin E, EP2 Subtype--metabolism Receptors, Prostaglandin E, EP4 Subtype--metabolism Rheology--drug effects Signal Transduction--drug effects Stress, Mechanical beta Catenin--metabolism